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There was a long debate about the potential photoreceptor molecule in Euglena including carotenoids flavins and rhodopsins This discussion was terminated by the unambiguous proof that the photoreceptor is a 400 kDa photoactivated adenylyl cyclase PAC which consists of two α
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Proof of principle experiments include light control of an engineered transcription factor that consisted of a bacterial DNA binding domain fused to the VP64 transcriptional activator sequence a nuclear export sequence and a LINuS domain and optical control of p53 transcriptional activity using the LEXY approach Niopek et al 2014 Niopek
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